Newborn granule cells show high excitability that disappears as the cells mature. Little has been known about the mechanisms that create low excitability in mature cells or how excitability of the newborn granule cells changes over time. Now University of Alabama at Birmingham researchers have described key roles for G protein-mediated signaling and the late maturation of an ion channel during the differentiation of granule cells. Their study is published in The Journal of Neuroscience.
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