Researchers can count on improved proteomics method

Princeton’s Martin Wühr has improved upon his method to accurately count the proteins present in a cell under different circumstances. ‘The TMTc+ method is in a kind of sweet spot compared to the other methods [of isobaric tagging],’ Wühr says. ‘It provides superb measurement accuracy and precision, it’s at least as sensitive as any other method, and it’s compatible with around ten times more mass spectrometers than TMT-MS3.’

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