Shaken, and stirred: Scaling up bioreactors’ fluid dynamics

Bioreactors are used to produce different therapeutics in the biopharmaceutical and regenerative medicine industries. Drug development relies on small multi-well plates shaken around an orbital diameter, while production-scale bioreactors are agitated by stirring. These different methods yield different fluid dynamics. Researchers in the U.K. are starting to bridge this gap by applying analytical techniques for stirred bioreactors to the fluid dynamics of orbitally shaken bioreactors. They discuss their work in this week’s Physics of Fluids.

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