A new twist to an old story of cellular signaling in the eye of a fly

Recent work from the National Centre for Biological Sciences (NCBS), Bangalore, has shown that the regeneration of a signaling molecule, phosphatidylinositol 4,5 bisphosphate (PIP2), is not as simple as it was thought to be. Experimental work from Raghu Padinjat’s group and mathematical modelling by Sandeep Krishna’s team from the Simons Centre for Living Machines at NCBS shows that the decades-old model of the biochemical cycle may have two unknown steps that could change the way scientists interpret experimental data.

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