Supercoiling pushes molecular handcuffs along chromatin fibers

As it squeezes down the chromatin fiber, the cohesin protein complex extrudes a growing loop of DNA — a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein? A team of SIB scientists has found that the driving force could be the supercoiling of upstream DNA. Their research, published in Nucleic Acids Research, is thereby adding a key piece to the puzzle of gene expression regulation. …read more

Source: EurekAlert

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