Researchers develop antidote for poisonous digoxin

In 2003, the “Angel of Death” Charles Cullen admitted to the murder of 40 hospital patients across New Jersey and Pennsylvania.

Cullen, a former nurse, used the cardiac drug digoxin as his weapon to commit his crimes over a period of 16 years.

Ten years later, a team of Rutgers and University of Washington chemists has developed an antidote to the poisonous drug.

In a “Nature” paper entitled “Computational Design of Ligand Binding Proteins with High Affinity and Selectivity,” the chemists introduce DIG10.3, a protein that binds to, and therefore inhibits, digoxin.

DIG10.3 binds to the digoxin molecule as tightly as a …read more

Source: The Daily Targum

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